Carboxyglutamic acid

Carboxyglutamic acid
Names
Systematic IUPAC name
3-Aminopropane-1,1,3-tricarboxylic acid
Other names
γ-Carboxyglutamate
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.054.607
UNII
  • InChI=1/C6H9NO6/c7-3(6(12)13)1-2(4(8)9)5(10)11/h2-3H,1,7H2,(H,8,9)(H,10,11)(H,12,13)
    Key: UHBYWPGGCSDKFX-UHFFFAOYAH
  • O=C(O)C(C(=O)O)CC(N)C(=O)O
Properties
C6H9NO6
Molar mass 191.14 g/mol
Density 1.649 g/mL
Boiling point 418 °C (784 °F; 691 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Carboxyglutamic acid (or the conjugate base, carboxyglutamate), is an uncommon amino acid introduced into proteins by a post-translational carboxylation of glutamic acid residues. This modification is found, for example, in clotting factors and other proteins of the coagulation cascade. This modification introduces an affinity for calcium ions. In the blood coagulation cascade, vitamin K is required to introduce γ-carboxylation of clotting factors II, VII, IX, X and protein Z.

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