Gliclazide

Gliclazide
Clinical data
Trade names	Diamicron, Diaprel, Azukon, others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	AU: C;
Routes of; administration	By mouth
ATC code	A10BB09 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only);
Pharmacokinetic data
Elimination half-life	10.4 hours
Identifiers
	IUPAC name N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide;
CAS Number	21187-98-4 ;
PubChem CID	3475;
DrugBank	DB01120 ;
ChemSpider	3356 ;
UNII	G4PX8C4HKV;
KEGG	D01599 ;
ChEBI	CHEBI:31654 ;
ChEMBL	ChEMBL427216 ;
CompTox Dashboard (EPA)	DTXSID9023095 ;
ECHA InfoCard	100.040.221
Chemical and physical data
Formula	C15H21N3O3S
Molar mass	323.41 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	180 to 182 °C (356 to 360 °F)
	SMILES O=S(=O)(c1ccc(cc1)C)NC(=O)NN3CC2CCCC2C3;
	InChI InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19) ; Key:BOVGTQGAOIONJV-UHFFFAOYSA-N ;
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Gliclazide, sold under the brand name Diamicron among others, is a sulfonylurea type of anti-diabetic medication, used to treat type 2 diabetes. It is used when dietary changes, exercise, and weight loss are not enough. It is taken by mouth.

Side effect may include low blood sugar, vomiting, abdominal pain, rash, and liver problems. Use by those with significant kidney problems or liver problems or who are pregnant is not recommended. Gliclazide is in the sulfonylurea family of medications. It works mostly by increasing the release of insulin.

Gliclazide was patented in 1966 and approved for medical use in 1972. It is on the World Health Organization's List of Essential Medicines. It is not available for sale in the United States.