Secretin family
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | Hormone_2 | ||||||||
| Pfam | PF00123 | ||||||||
| InterPro | IPR000532 | ||||||||
| PROSITE | PDOC00233 | ||||||||
| SCOP2 | 1gcn / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 145 | ||||||||
| OPM protein | 1gcn | ||||||||
| |||||||||
Glucagon/gastric inhibitory polypeptide/secretin/vasoactive intestinal peptide hormones are a family of evolutionarily related peptide hormones that regulate activity of G-protein-coupled receptors from the secretin receptor family. A number of polypeptidic hormones, mainly expressed in the intestine or the pancreas, belong to a group of these structurally related peptides.
This family of hormones are produced from (preproglucagon), which is cleaved to produce glucagon, glucagon-like protein I, glucagon-like protein II, and glicentin. Other members of the structurally similar group include secretin, gastric inhibitory peptide, vasoactive intestinal peptide, prealbumin, peptide HI-27, and growth hormone releasing factor.
One hormone, glucagon, is fully conserved in all mammalian species in which it has been studied.