Glucose-1,6-bisphosphate synthase
| Glucose-1,6-bisphosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.106 | ||||||||
| CAS no. | 56214-39-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Glucose-1,6-bisphosphate synthase is a type of enzyme called a phosphotransferase and is involved in mammalian starch and sucrose metabolism (KEGG, 2.7.1.106 Archived 2011-07-16 at the Wayback Machine). It catalyzes the transfer of a phosphate group from 1,3-bisphosphoglycerate to glucose-1-phosphate, yielding 3-phosphoglycerate and glucose-1,6-bisphosphate.
(image courtesy of the BRENDA enzyme database)
The enzyme requires a divalent metal ion cofactor. Zinc (Zn2+), Magnesium (Mg2+), Manganese (Mn2+), Calcium (Ca2+), Nickel (Ni2+), Copper (Cu2+), Cadmium (Cd2+) are all proven effective cofactors in vitro. Additionally, the enzyme appears to function optimally in a pH range from 7.3–8.7 and at a temperature of 25 °C.