Gonadotropin-releasing hormone

GNRH1

Identifiers

GNRH1, GNRH, GRH, HH12, LHRH, LNRH, gonadotropin releasing hormone 1, Gonadotropin-Releasing Hormone

External IDs

OMIM: 152760; MGI: 95789; HomoloGene: 641; GeneCards: GNRH1; OMA:GNRH1 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)

Band	8p21.2	Start	25,419,258 bp
Band	8p21.2	End	25,424,654 bp

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)

Band	14\|14 D1	Start	67,982,630 bp
Band	14\|14 D1	End	67,986,888 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tibial nerve

testicle

cerebellar hemisphere

putamen

ascending aorta

Descending thoracic aorta

mucosa of transverse colon

right hemisphere of cerebellum

popliteal artery

tibial arteries

Top expressed in

primary oocyte

bone marrow

embryonic cell

zygote

secondary oocyte

morula

neural layer of retina

granulocyte

thymus

preoptic area

More reference expression data


More reference expression data

Gene ontology
Molecular function	hormone activity gonadotropin hormone-releasing hormone activity gonadotropin-releasing hormone receptor binding
Cellular component	axon terminus perikaryon Golgi-associated vesicle extracellular region neurosecretory vesicle dendrite mitochondrion neuron projection cytoplasmic side of rough endoplasmic reticulum membrane extracellular space
Biological process	negative regulation of immature T cell proliferation response to prolactin negative regulation of neuron migration response to potassium ion response to organic cyclic compound response to testosterone estrous cycle female pregnancy cell-cell signaling response to steroid hormone ageing response to peptide hormone negative regulation of apoptotic process male sex determination multicellular organism development response to prostaglandin E response to lipopolysaccharide response to corticosteroid regulation of gene expression ovulation cycle response to ethanol regulation of ovarian follicle development signal transduction negative regulation of cell population proliferation regulation of signaling receptor activity G protein-coupled receptor signaling pathway reproduction
Sources:Amigo / QuickGO

Species

Human

Mouse


2796


14714


ENSG00000147437


ENSMUSG00000015812


P01148


P13562

RefSeq (mRNA)


NM_001083111 NM_000825


NM_008145

RefSeq (protein)


NP_000816 NP_001076580


NP_032171

Location (UCSC)

Chr 8: 25.42 – 25.42 Mb

Chr 14: 67.98 – 67.99 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus. GnRH is inhibited by testosterone. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis.