Gram domain-containing 2A

GRAMD2A
Identifiers
Aliases	GRAMD2A, GRAMD2, GRAM domain containing 2A
External IDs	MGI: 3528937; HomoloGene: 52791; GeneCards: GRAMD2A; OMA:GRAMD2A - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	72,197,787 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	59,626,157 bp
RNA expression pattern
	Top expressed in
	tibia; ; placenta; ; right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right lung; ; olfactory zone of nasal mucosa; ; tail of epididymis; ; corpus epididymis; ; upper lobe of left lung;
	Top expressed in
	layer of retina; ; neural layer of retina; ; lung; ; placenta; ; granulocyte; ; testicle; ; outer nuclear layer; ; zone of skin; ; secondary oocyte; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol binding; lipid binding;
Cellular component	membrane; integral component of membrane; intrinsic component of endoplasmic reticulum membrane; extrinsic component of cytoplasmic side of plasma membrane; organelle membrane contact site; endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane;
Biological process	endoplasmic reticulum-plasma membrane tethering; regulation of store-operated calcium entry;
	Sources:Amigo / QuickGO
Orthologs
	196996
	546134
	ENSG00000175318
	ENSMUSG00000074259
	Q8IUY3
	Q3V3G7
	NM_001012642
	NM_001033498; NM_001357686; NM_001379375; NM_001379376; NM_001379377
	NP_001012660
	NP_001028670; NP_001344615; NP_001366304; NP_001366305; NP_001366306
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain-containing 2A protein (GRAMD2A; formerly GRAMD2) is a protein encoded by the GRAMD2A gene. Like GRAMD2B, the protein consists of a GRAM domain and a transmembrane domain that anchors it to the endoplasmic reticulum.

GRAMD2A is a mammalian representative of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family. It has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2B. Unlike LAM and its paralogs except GRAMD2B, GRAMD2A lacks a VASt domain.

The protein localizes to sites where membranes from different organelles are in close apposition. There, it tethers the endoplasmic reticulum to the plasma membrane through its GRAM domain binding phosphatidylinositol 4,5-bisphosphate in the plasma membrane at sites enriched for the phospholipid. The protein ensures proper stromal interaction molecule 1 (STIM1) recruitment to these sites of membrane contact as part of the store-operated calcium entry pathway – a component of intracellular calcium homeostasis.