Guillain–Barré syndrome
| Guillain–Barré syndrome | |
|---|---|
| Other names | Guillain–Barré–Strohl syndrome, Landry's paralysis, postinfectious polyneuritis, Acute Inflammatory Demyelinating Polyneuropathy |
| Pronunciation | |
| Specialty | Neurology |
| Symptoms | Muscle weakness beginning in the feet and hands, usually ascending |
| Complications | Breathing difficulties, heart and blood pressure problems |
| Usual onset | Rapid (hours to weeks) |
| Causes | Typically triggered by an infection; occasionally by surgery |
| Diagnostic method | Based on symptoms, nerve conduction studies, lumbar puncture |
| Treatment | Supportive care, intravenous immunoglobulin, plasmapheresis |
| Prognosis | Weeks to years for recovery |
| Frequency | 2 per 100,000 people per year |
| Deaths | 7.5% of those affected |
| Named after | |
Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain often in the back along with muscle weakness, beginning in the feet and hands, often spreading to the arms and upper body. The symptoms may develop over hours to a few weeks. During the acute phase, the disorder can be life-threatening, with about 15% of people developing respiratory muscle weakness requiring mechanical ventilation. Some are affected by changes in the function of the autonomic nervous system, which can lead to dangerous abnormalities in heart rate and blood pressure.
Although the cause is unknown, the underlying mechanism involves an autoimmune disorder in which the body's immune system mistakenly attacks the peripheral nerves and damages their myelin insulation. Sometimes this immune dysfunction is triggered by an infection or, less commonly, by surgery, and by vaccination. The diagnosis is usually based on the signs and symptoms through the exclusion of alternative causes and supported by tests such as nerve conduction studies and examination of the cerebrospinal fluid. There are several subtypes based on the areas of weakness, results of nerve conduction studies, and the presence of certain antibodies. It is classified as an acute polyneuropathy.
In those with severe weakness, prompt treatment with intravenous immunoglobulins or plasmapheresis, together with supportive care, will lead to good recovery in the majority of cases. Recovery may take weeks to years, with about a third having some permanent weakness. Globally, death occurs in approximately 7.5% of those affected. Guillain–Barré syndrome is rare, at 1 or 2 cases per 100,000 people every year. The illness that afflicted US president Franklin D. Roosevelt, and left him paralysed from the waist down, which was believed at the time to be polio, may have been Guillain–Barré syndrome, according to more recent research.
The syndrome is named after the French neurologists Georges Guillain and Jean Alexandre Barré, who, together with French physician André Strohl, described the condition in 1916.