HIST1H1D

H1-3
Identifiers
Aliases	H1-3, H1.3, H1D, H1F3, H1s-2, histone cluster 1, H1d, histone cluster 1 H1 family member d, H1.3 linker histone, cluster member, HIST1H1D
External IDs	OMIM: 142210; MGI: 107502; HomoloGene: 68456; GeneCards: H1-3; OMA:H1-3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	26,234,987 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	23,744,860 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gonad; ; epithelium of colon; ; bone marrow cells; ; testicle; ; ventricular zone; ; tonsil; ; embryo; ; sural nerve; ; ganglionic eminence;
	Top expressed in
	gray matter layer of cerebellum; ; seminiferous tubule; ; hair follicle; ; mandibular prominence; ; primitive streak; ; abdominal wall; ; ascending aorta; ; aortic valve; ; fossa; ; endothelial cell of lymphatic vessel;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; chromatin DNA binding; RNA binding; double-stranded DNA binding; protein binding; nucleosomal DNA binding;
Cellular component	nucleosome; nucleus; chromosome;
Biological process	regulation of transcription by RNA polymerase II; histone H3-K4 trimethylation; nucleosome assembly; negative regulation of transcription by RNA polymerase II; histone H3-K27 trimethylation; regulation of transcription, DNA-templated; chromosome condensation; negative regulation of DNA recombination;
	Sources:Amigo / QuickGO
Orthologs
	3007
	14957
	ENSG00000124575
	ENSMUSG00000052565
	P16402
	P43277
	NM_005320
	NM_145713
	NP_005311
	NP_663759
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H1.3 is a protein encoded by the HIST1H1D gene in humans.

Histones are basic nuclear proteins that play a crucial role in the nucleosome structure of chromosomal fibers in eukaryotes. Two molecules each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped to create repeating units called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and facilitates the compaction of chromatin into higher-order structures. This intronless gene encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails and instead contain a palindromic termination element. This gene is located within the large histone gene cluster on chromosome 6.