HIST1H1E

H1-4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TZD, 5JJZ
Identifiers
Aliases	H1-4, histone cluster 1, H1e, H1.4, H1E, H1F4, H1s-4, dJ221C16.5, histone cluster 1 H1 family member e, RMNS, HIST1H1E, H1.4 linker histone, cluster member
External IDs	OMIM: 142220; MGI: 1931527; HomoloGene: 130534; GeneCards: H1-4; OMA:H1-4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	26,157,115 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	23,806,541 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; tendon of biceps brachii; ; sural nerve; ; epithelium of colon; ; testicle; ; bone marrow cells; ; gonad; ; corpus callosum; ; secondary oocyte; ; muscle of thigh;
	Top expressed in
	genital tubercle; ; ascending aorta; ; aortic valve; ; tail of embryo; ; embryo; ; muscle of thigh; ; embryo; ; granulocyte; ; zygote; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; chromatin DNA binding; protein binding; RNA binding; nucleotide binding; double-stranded DNA binding; calcium ion binding; ATP binding; GTP binding; AMP binding; dATP binding; ADP binding; nucleosomal DNA binding;
Cellular component	nucleosome; extracellular exosome; nucleus; chromosome;
Biological process	regulation of transcription by RNA polymerase II; histone H3-K4 trimethylation; nucleosome assembly; negative regulation of transcription by RNA polymerase II; histone H3-K27 trimethylation; regulation of transcription, DNA-templated; chromosome condensation; negative regulation of DNA recombination;
	Sources:Amigo / QuickGO
Orthologs
	3008
	50709
	ENSG00000168298
	ENSMUSG00000051627
	P10412
	P43274
	NM_005321
	NM_015787
	NP_005312; NP_005312.1
	NP_056602
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H1.4 is a protein that in humans is encoded by the HIST1H1E gene.

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.