HIST1H1T

H1-6
Identifiers
Aliases	H1-6, H1FT, H1t, dJ221C16.2, H1.6, histone cluster 1, H1t, histone cluster 1 H1 family member t, HIST1H1T, H1.6 linker histone, cluster member
External IDs	OMIM: 142712; MGI: 1888530; HomoloGene: 3889; GeneCards: H1-6; OMA:H1-6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	26,108,135 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	23,880,708 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; monocyte; ; corpus callosum; ; blood; ; left testis; ; right testis; ; islet of Langerhans; ; right lung; ; human musculoskeletal system;
	Top expressed in
	spermatocyte; ; spermatid; ; embryo; ; embryo; ; pharynx; ; lesser wing of sphenoid bone; ; gray matter layer of cerebellum; ; perirhinal cortex; ; entorhinal cortex; ; choroid plexus of fourth ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; double-stranded DNA binding; protein binding; nucleosomal DNA binding;
Cellular component	nucleosome; nucleus; chromosome; condensed nuclear chromosome;
Biological process	multicellular organism development; nucleosome assembly; cell differentiation; spermatogenesis; regulation of transcription, DNA-templated; binding of sperm to zona pellucida; chromosome condensation; flagellated sperm motility; negative regulation of DNA recombination;
	Sources:Amigo / QuickGO
Orthologs
	3010
	107970
	ENSG00000187475
	ENSMUSG00000036211
	P22492
	Q07133
	NM_005323
	NM_010377
	NP_005314
	NP_034507
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H1t is a protein that in humans is encoded by the HIST1H1T gene.

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.