H19 (gene)

H19
Identifiers
Aliases	H19, BWS, LINC00008, ASM1, NCRNA00008, imprinted maternally expressed transcript, D11S813E, MIR675HG, imprinted maternally expressed transcript (non-protein coding), H19 imprinted maternally expressed transcript, WT2, PRO2605, ASM
External IDs	OMIM: 103280; GeneCards: H19; OMA:H19 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	2,001,470 bp
RNA expression pattern
	Top expressed in
	placenta; ; muscle of thigh; ; apex of heart; ; right adrenal cortex; ; gastrocnemius muscle; ; left adrenal cortex; ; skeletal muscle tissue; ; left uterine tube; ; left ventricle; ; canal of the cervix;
	n/a
	More reference expression data
	More reference expression data
Orthologs
	283120
	n/a
	ENSG00000130600; ENSG00000288237
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

H19 is a gene for a long noncoding RNA, found in humans and elsewhere. H19 has a role in the negative regulation (or limiting) of body weight and cell proliferation. This gene also has a role in the formation of some cancers and in the regulation of gene expression.

The H19 gene is expressed exclusively on one parental allele in a phenomenon known as imprinting. H19 is only transcribed from the maternally inherited allele; the paternal H19 allele is not expressed. H19 was first named ASM (for Adult Skeletal Muscle) because of its expression in adult skeletal muscle ("ASM") in rats. H19 is also known as BWS because aberrant H19 expression can be involved in Beckwith-Wiedemann Syndrome ("BWS"), as well as Silver-Russell syndrome. Epigenetics deregulations at H19 imprinted gene in sperm have been observed associated with male infertility.