HIST2H2AB

H2AC21
Identifiers
Aliases	H2AC21, H2AB, histone cluster 2, H2ab, histone cluster 2 H2A family member b, H2A clustered histone 21, HIST2H2AB
External IDs	OMIM: 615014; MGI: 2448314; HomoloGene: 111318; GeneCards: H2AC21; OMA:H2AC21 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	149,887,965 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,127,624 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; bone marrow cells; ; testicle; ; corpus callosum; ; epithelium of colon; ; granulocyte; ; sural nerve; ; tonsil; ; blood; ; urinary bladder;
	Top expressed in
	genital tubercle; ; spermatocyte; ; morula; ; uterus; ; embryo; ; embryo; ; tail of embryo; ; urinary bladder; ; spermatid; ; striatum of neuraxis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein heterodimerization activity; molecular function;
Cellular component	nucleosome; extracellular exosome; nucleus; chromosome;
Biological process	chromatin organization; biological process;
	Sources:Amigo / QuickGO
Orthologs
	317772
	621893
	ENSG00000184270
	ENSMUSG00000063689
	Q8IUE6
	Q64522
	NM_175065
	NM_178213
	NP_778235
	NP_835585
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2A type 2-B is a protein that in humans is encoded by the HIST2H2AB gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.