HIST1H2AE

H2AC8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CV5, 3A6N, 3AFA, 3AN2, 3AV1, 3AV2, 3AYW, 3AZE, 3AZF, 3AZG, 3AZH, 3AZI, 3AZJ, 3AZK, 3AZL, 3AZM, 3AZN, 3W96, 3W97, 3W98, 3W99, 3WKJ, 3WTP, 5CPJ, 5B0Z, 4YM5, 5AV9, 5AVB, 5AV5, 4YM6, 5CPI, 3X1V, 5AV6, 3X1S, 5AV8, 5CPK, 5AVC, 5B0Y, 4Z5T, 5B24, 2RVQ, 5B40, 5AY8, 5B2I, 5B2J
Identifiers
Aliases	H2AC8, H2A.1, H2A.2, H2A/a, H2AFA, histone cluster 1, H2ae, histone cluster 1 H2A family member e, HIST1H2AE, H2A clustered histone 8, H2AC4
External IDs	OMIM: 602786; MGI: 2448457; HomoloGene: 135791; GeneCards: H2AC8; OMA:H2AC8 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	26,217,483 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	21,900,984 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; testicle; ; monocyte; ; gonad; ; bone marrow cells; ; right uterine tube; ; mucosa of transverse colon; ; prostate; ; amniotic fluid; ; epithelium of colon;
	Top expressed in
	uterus; ; spermatid; ; yolk sac; ; embryo; ; bone marrow; ; genital tubercle; ; embryo; ; Mesencephalon; ; neural tube; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein heterodimerization activity; protein binding;
Cellular component	nucleosome; extracellular exosome; nucleus; chromosome;
Biological process	negative regulation of cell population proliferation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	3012
	319191
	ENSG00000277075
	ENSMUSG00000071516
	P04908
C0HKE2; B2RVF0; C0HKE1; C0HKE3; C0HKE5;
	C0HKE4; C0HKE6; C0HKE7; C0HKE8; C0HKE9
	NM_021052
	NM_178182
	NP_003504
NP_835496; NP_835495; NP_835494; NP_835491; NP_835489;
	NP_783591; NP_835493; NP_835496; NP_835489; NP_835495; NP_835494; NP_835491; NP_835492; NP_783591; NP_001171015; NP_835489; NP_001171015; NP_835496; NP_835491; NP_835493; NP_835494; NP_835495; NP_835492; NP_783591; NP_835495; NP_835489; NP_835494; NP_835491; NP_835492; NP_783591; NP_001171015; NP_835493; NP_835496; NP_835494; NP_835489; NP_835495; NP_835491; NP_835492; NP_783591; NP_001171015; NP_835493; NP_835496; NP_835492; NP_835491; NP_835489; NP_835495; NP_835494; NP_783591; NP_001171015; NP_835493; NP_835496; NP_835491; NP_835489; NP_835495; NP_835494; NP_835492; NP_783591; NP_001171015; NP_835493; NP_835496; NP_783591; NP_835489; NP_835495; NP_835494; NP_835491; NP_835492; NP_001171015; NP_835493; NP_835496; NP_783591; NP_835489; NP_835495; NP_835494; NP_835491; NP_835492; NP_001171015; NP_835493; NP_835496
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AE gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4).

The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.