H2AFX

H2AX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D31, 2DYP, 3SHV, 3SQD, 3SZM, 1YDP, 2AZM, 3U3Z
Identifiers
Aliases	H2AX, H2A.X, H2A/X, H2A histone family member X, H2A.X variant histone, H2AFX
External IDs	OMIM: 601772; MGI: 102688; HomoloGene: 134201; GeneCards: H2AX; OMA:H2AX - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,095,465 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,247,374 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; ganglionic eminence; ; mucosa of transverse colon; ; oocyte; ; inferior ganglion of vagus nerve; ; thymus; ; trabecular bone; ; C1 segment; ; subthalamic nucleus;
	Top expressed in
	medial ganglionic eminence; ; abdominal wall; ; maxillary prominence; ; mandibular prominence; ; tail of embryo; ; tibiofemoral joint; ; genital tubercle; ; epiblast; ; somite; ; ventricular zone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; histone binding; protein binding; protein heterodimerization activity; enzyme binding; damaged DNA binding;
Cellular component	nucleoplasm; chromosome; telomere; nucleosome; extracellular exosome; nuclear speck; centrosome; nucleus; site of double-strand break; chromatin; condensed nuclear chromosome; male germ cell nucleus; XY body; replication fork; site of DNA damage;
Biological process	response to ionizing radiation; nucleosome assembly; DNA recombination; DNA damage checkpoint signaling; positive regulation of DNA repair; cellular response to DNA damage stimulus; cellular senescence; meiosis; cellular response to gamma radiation; spermatogenesis; cerebral cortex development; cell cycle; viral process; double-strand break repair via nonhomologous end joining; double-strand break repair; DNA repair; double-strand break repair via homologous recombination; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	3014
	15270
	ENSG00000188486
	ENSMUSG00000049932
	P16104
	P27661
	NM_002105
	NM_010436
	NP_002096
	NP_034566
	Wikidata
View/Edit Human	View/Edit Mouse

H2A histone family member X (usually abbreviated as H2AX) is a type of histone protein from the H2A family encoded by the H2AFX gene. An important phosphorylated form is γH2AX (S139), which forms when double-strand breaks appear.

In humans and other eukaryotes, the DNA is wrapped around histone octamers, consisting of core histones H2A, H2B, H3 and H4, to form chromatin. H2AX contributes to nucleosome-formation, chromatin-remodeling and DNA repair, and is also used in vitro as an assay for double-strand breaks in dsDNA.