HIST1H2BK

H2BC12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CV5
Identifiers
Aliases	H2BC12, H2B/S, H2BFAiii, H2BFT, H2BK, histone cluster 1, H2bk, histone cluster 1 H2B family member k, H2B clustered histone 12, HIST1H2BK
External IDs	OMIM: 615045; MGI: 2448399; HomoloGene: 135980; GeneCards: H2BC12; OMA:H2BC12 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	27,146,855 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	22,220,515 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; monocyte; ; blood; ; Achilles tendon; ; placenta; ; mucosa of transverse colon; ; spleen; ; gonad; ; prostate; ; fallopian tube;
	Top expressed in
	uterus; ; zygote; ; secondary oocyte; ; primary oocyte; ; white adipose tissue; ; bone marrow; ; adrenal gland; ; spermatid; ; urinary bladder; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein heterodimerization activity; molecular function;
Cellular component	nucleoplasm; nucleosome; nucleus; chromosome; extracellular space; cytosol;
Biological process	nucleosome assembly; innate immune response in mucosa; defense response to bacterium; protein ubiquitination; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	85236
	319184
	ENSG00000197903
	ENSMUSG00000062727
	O60814
	Q8CGP1
	NM_080593; NM_001312653
	NM_175665
	NP_001299582; NP_542160
	NP_783596
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.