H3F3A

H3-3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H9O, 5BNX, 3JVK, 5DWQ, 4L58, 4TMP, 5DX0, 4H9S, 4W5A, 3AV2, 3WTP, 4HGA, 4GUS, 4GY5, 3MUK, 3QLC, 4H9Q, 4N4I, 4GU0, 4GNE, 5BNV, 2L43, 3MUL, 4H9P, 3QLA, 4QQ4, 4GNF, 4U7T, 3ASK, 4O62, 4GNG, 4GUR, 4H9N, 4H9R, 3ASL, 3QL9, 5AY8, 5JA4
Identifiers
Aliases	H3-3A, H3.3A, H3F3, H3 histone, family 3A, H3 histone family member 3A, H3.3 histone A, H3F3A, H3-3B
External IDs	OMIM: 601128; MGI: 1097686; HomoloGene: 134170; GeneCards: H3-3A; OMA:H3-3A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	226,073,212 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	180,641,508 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; monocyte; ; blood; ; endometrium; ; rectum; ; corpus callosum; ; granulocyte; ; appendix; ; gallbladder;
	Top expressed in
	ganglionic eminence; ; neural tube; ; Mesencephalon; ; granulocyte; ; ventricular zone; ; thymus; ; lip; ; bone marrow; ; ileum; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; histone binding; protein binding; protein heterodimerization activity; RNA polymerase II core promoter sequence-specific DNA binding; nucleosomal DNA binding;
Cellular component	nucleoplasm; chromosome; extracellular region; nuclear chromosome; extracellular exosome; Barr body; nucleosome; nucleus; protein-containing complex;
Biological process	telomere organization; epigenetic maintenance of chromatin in transcription-competent conformation; blood coagulation; positive regulation of cell growth; rDNA heterochromatin assembly; negative regulation of gene expression, epigenetic; male gonad development; multicellular organism growth; single fertilization; cell population proliferation; embryo implantation; negative regulation of chromosome condensation; spermatid development; nucleus organization; osteoblast differentiation; pericentric heterochromatin assembly; oogenesis; subtelomeric heterochromatin assembly; spermatogenesis; regulation of centromere complex assembly; muscle cell differentiation; nucleosome assembly; brain development; response to hormone; regulation of gene silencing by miRNA; regulation of megakaryocyte differentiation; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3020
	15078
	ENSG00000163041
	ENSMUSG00000060743
	P84243
	P84244
	NM_002107
	NM_008210
	NP_005315
	NP_032236; NP_032237
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H3.3 is a protein that in humans is encoded by the H3F3A and H3F3B genes. It plays an essential role in maintaining genome integrity during mammalian development.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.

Mutation of H3F3A are also linked to certain cancers. p.Lys27Met were discovered in Diffuse Intrinsic Pontine Glioma (DIPG), where they are present 65-75% of tumors and confer a worse prognosis. p.Lys27Met alterations in HIST1H3B and HIST1H3C, which code for histone H3.1 have also been reported in ~10% of DIPG. H3F3A is also mutated in a smaller portion of pediatric and young adult high grade astrocytomas but more frequently as p.Gly34Arg/Val. Mutations in H3F3A and H3F3B are also found in chondroblastoma and giant cell tumor of bone.