HIST1H3G

H3C8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WKJ, 3B95, 2C1J, 3AYW, 3WA9, 3U4S, 5AVB, 2CV5, 5AV5, 3U31, 2UXN, 3AZK, 2C1N, 5C11, 3QO2, 3X1V, 5C13, 4A0J, 4U68, 5AV8, 4LLB, 3U5O, 1O9S, 4FT2, 4HON, 3W99, 3ZVY, 4Z0R, 5AVC, 1CT6, 1Q3L, 3O37, 3W97, 3SOW, 3KMT, 4YM6, 4A7J, 3UEE, 2KWK, 4F4U, 3UEF, 3UIG, 4BD3, 3AZL, 4QBR, 4F56, 3AFA, 4LKA, 5CPK, 5FFV, 3V43, 5CH1, 3U5P, 3AZI, 3U5N, 3AZH, 3UIK, 4QBQ, 1U35, 4UY4, 2OT7, 5AV9, 2B2W, 3U3D, 3AZF, 3W98, 4I51, 4X3K, 4FWF, 2B2T, 2B2V, 4A0N, 2KWJ, 3WAA, 3QJ6, 5DAH, 3AZG, 3AZE, 3X1T, 3RIY, 2L75, 3A1B, 2VPG, 4QBS, 3O35, 5CPJ, 3ZG6, 4YM5, 3AZJ, 2RI7, 3AZN, 3AVR, 5CPI, 2LBM, 3W96, 3O34, 2M0O, 4L7X, 5CH2, 5AV6, 3AZM, 4UP0, 3X1S, 2OX0, 3UII, 3SOU, 4N4H, 4TN7, 1CS9, 3X1U, 4LXL, 2B2U, 2OQ6, 3RIG, 5C3I, 4YHP, 5B24, 5D6Y, 4YHZ, 4Z2M, 5HJD, 5HJC, 5HJB, 5B2I, 5HYN, 5FB0, 5FB1, 5IQL, 5B2J, 5JIN
Identifiers
Aliases	H3C8, H3/h, H3FH, histone cluster 1, H3g, histone cluster 1 H3 family member g, HIST1H3G, H3 clustered histone 8, H3C4, H3C7, H3C12, H3C2, H3C10, H3C3, H3C6, H3C1, H3C11
External IDs	OMIM: 602815; MGI: 2448357; HomoloGene: 134485; GeneCards: H3C8; OMA:H3C8 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	26,271,413 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,146,443 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; gonad; ; ventricular zone; ; epithelium of colon; ; mucosa of transverse colon; ; tonsil; ; ganglionic eminence; ; duodenum; ; rectum; ; lymph node;
	Top expressed in
	lacrimal gland; ; retinal pigment epithelium; ; zygote; ; calvaria; ; olfactory epithelium; ; epithelium of lens; ; Epithelium of choroid plexus; ; decidua; ; parotid gland; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; histone binding; protein binding; protein heterodimerization activity; cadherin binding; nucleosomal DNA binding;
Cellular component	membrane; nucleoplasm; chromosome; extracellular region; nuclear chromosome; extracellular exosome; nucleosome; nucleus; protein-containing complex;
Biological process	telomere organization; epigenetic maintenance of chromatin in transcription-competent conformation; protein heterotetramerization; blood coagulation; DNA replication-dependent chromatin assembly; rDNA heterochromatin assembly; negative regulation of gene expression, epigenetic; chromatin organization; regulation of gene silencing by miRNA; nucleosome assembly; interleukin-7-mediated signaling pathway; regulation of megakaryocyte differentiation; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	8355
	97114
	ENSG00000273983
	ENSMUSG00000081058
	P68431
	P84228
	NM_003534
	NM_054045
	NP_066298; NP_003520; NP_003525; NP_003527
NP_473386; NP_835734; NP_783584; NP_835510; NP_835587;
	NP_038576; NP_835511; NP_835512
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H3.1 is a protein that in humans is encoded by the HIST1H3G gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.