HIST1H4A

H4C1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifiers
Aliases	H4C1, H4FA, histone cluster 1, H4a, histone cluster 1 H4 family member a, HIST1H4A, H4 clustered histone 1, H4C5, H4C4, H4C9, H4C12, H4-16, H4C3, H4C13, H4C11, H4C14, H4C15, H4C8, H4C6, H4C2
External IDs	OMIM: 602822; MGI: 2448423; HomoloGene: 134481; GeneCards: H4C1; OMA:H4C1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	26,022,050 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	23,766,718 bp
RNA expression pattern
	Top expressed in
	testicle; ; bone marrow cells; ; epithelium of colon; ; gonad; ; Achilles tendon; ; tonsil; ; ventricular zone; ; appendix; ; mucosa of transverse colon; ; granulocyte;
	Top expressed in
	uterus; ; genital tubercle; ; Mesencephalon; ; blastocyst; ; embryo; ; neural tube; ; morula; ; tail of embryo; ; embryo; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein domain specific binding; protein binding; protein heterodimerization activity; DNA binding; histone binding; RNA binding;
Cellular component	membrane; chromosome; nucleoplasm; extracellular region; nuclear chromosome; nucleosome; extracellular exosome; nucleus; extracellular matrix; protein-containing complex;
Biological process	telomere organization; epigenetic maintenance of chromatin in transcription-competent conformation; protein heterotetramerization; negative regulation of megakaryocyte differentiation; CENP-A containing chromatin assembly; DNA replication-dependent chromatin assembly; rDNA heterochromatin assembly; negative regulation of gene expression, epigenetic; DNA-templated transcription, initiation; double-strand break repair via nonhomologous end joining; beta-catenin-TCF complex assembly; telomere capping; nucleosome assembly; regulation of gene silencing by miRNA; regulation of megakaryocyte differentiation; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	8359
	319156
	ENSG00000278637
	ENSMUSG00000061482
	P62805
	P62806
	NM_003538
	NM_175654
NP_003537; NP_003486; NP_003535; NP_003539; NP_003531;
	NP_003536
NP_291074; NP_783587; NP_783588; NP_835499; NP_835500;
	NP_001182350; NP_835515; NP_783585; NP_783586; NP_835582; NP_835583; NP_783583; NP_694813
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H4 is a protein that in humans is encoded by the HIST1H4A gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.