HABP2

HABP2
Identifiers
Aliases	HABP2, FSAP, HABP, HGFAL, PHBP, NMTC5, hyaluronan binding protein 2
External IDs	OMIM: 603924; MGI: 1196378; HomoloGene: 3050; GeneCards: HABP2; OMA:HABP2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	113,589,602 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	56,309,254 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; pancreatic ductal cell; ; gallbladder; ; oocyte; ; secondary oocyte; ; body of pancreas; ; islet of Langerhans; ; human kidney; ; gonad; ; muscle of thigh;
	Top expressed in
	right kidney; ; yolk sac; ; crypt of lieberkuhn of small intestine; ; liver; ; human kidney; ; left lobe of liver; ; proximal tubule; ; stomach; ; epithelium of stomach; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; glycosaminoglycan binding; serine-type peptidase activity; hydrolase activity; calcium ion binding; serine-type endopeptidase activity;
Cellular component	extracellular region; extracellular space;
Biological process	cell adhesion; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	3026
	226243
	ENSG00000148702
	ENSMUSG00000025075
	Q14520
	Q8K0D2
	NM_004132; NM_001177660
	NM_146101; NM_001329935; NM_001329936
	NP_001171131; NP_004123
	NP_001316864; NP_001316865; NP_666213
	Wikidata
View/Edit Human	View/Edit Mouse

Hyaluronan-binding protein 2 also known as factor VII activating protease (FSAP) is a protein that in humans is encoded by the HABP2 gene.

The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.