HAGH

HAGH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QH3, 1QH5
Identifiers
Aliases	HAGH, GLO2, GLX2, GLXII, HAGH1, hydroxyacylglutathione hydrolase
External IDs	OMIM: 138760; MGI: 95745; HomoloGene: 3890; GeneCards: HAGH; OMA:HAGH - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,827,157 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	25,083,424 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; gastrocnemius muscle; ; left adrenal cortex; ; prefrontal cortex; ; muscle of thigh; ; left testis;
	Top expressed in
	spermatid; ; right kidney; ; spermatocyte; ; left lobe of liver; ; blood; ; proximal tubule; ; seminiferous tubule; ; human kidney; ; facial motor nucleus; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydroxyacylglutathione hydrolase activity; protein binding; hydrolase activity; metal ion binding;
Cellular component	cytoplasm; cytosol; mitochondrial matrix; mitochondrion;
Biological process	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; glutathione biosynthetic process; pyruvate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3029
	14651
	ENSG00000063854
	ENSMUSG00000024158
	Q16775
	Q99KB8
	NM_001040427; NM_001286249; NM_005326; NM_001363912; NM_001363914
	NM_001159626; NM_024284
	NP_001035517; NP_001273178; NP_005317; NP_001350841; NP_001350843
	NP_001153098; NP_077246
	Wikidata
View/Edit Human	View/Edit Mouse

Hydroxyacylglutathione hydrolase, mitochondrial is an enzyme that in humans is encoded by the HAGH gene.

The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.