HCN4

HCN4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MNG, 3OTF, 3U11, 4HBN, 4KL1, 4NVP
Identifiers
Aliases	HCN4, SSS2, hyperpolarization activated cyclic nucleotide gated potassium channel 4, BRGDA8, EIG18
External IDs	OMIM: 605206; MGI: 1298209; HomoloGene: 3997; GeneCards: HCN4; OMA:HCN4 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	73,368,958 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	58,770,458 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; right atrium; ; right auricle of heart; ; apex of heart; ; testicle; ; left ventricle; ; secondary oocyte; ; right ventricle; ; gonad; ; mucosa of ileum;
	Top expressed in
	myocardium; ; cardiac muscles; ; Cardiac muscle tissue of myocardium; ; electrical conduction system of the heart; ; sinus venosus; ; right atrium; ; sinoatrial node; ; septum transversum; ; vein; ; left horn of sinus venosus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; potassium channel activity; cAMP binding; sodium channel activity; voltage-gated ion channel activity; ion channel activity; intracellular cAMP-activated cation channel activity; identical protein binding; voltage-gated potassium channel activity; voltage-gated sodium channel activity; voltage-gated potassium channel activity involved in SA node cell action potential depolarization;
Cellular component	integral component of membrane; membrane; intrinsic component of plasma membrane; plasma membrane; perinuclear region of cytoplasm; HCN channel complex;
Biological process	cellular response to cGMP; muscle contraction; sodium ion transmembrane transport; sodium ion transport; SA node cell action potential; regulation of membrane potential; regulation of ion transmembrane transport; cation transport; ion transport; blood circulation; regulation of membrane depolarization; regulation of heart rate; potassium ion transport; transmembrane transport; potassium ion transmembrane transport; regulation of cardiac muscle contraction; regulation of heart rate by cardiac conduction; cellular response to cAMP; membrane depolarization during cardiac muscle cell action potential; membrane depolarization during SA node cell action potential; sodium ion import across plasma membrane; regulation of cardiac muscle cell action potential involved in regulation of contraction; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	10021
	330953
	ENSG00000138622
	ENSMUSG00000032338
	Q9Y3Q4
	O70507
	NM_005477
	NM_001081192
	NP_005468
	NP_001074661
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene.

There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart. Some humans with bradycardia and Sick sinus syndrome have been shown to have mutations in their HCN4 gene. The role of HCN channels in autonomic control of heart rate is currently a matter of ongoing investigation.