HDAC11

HDAC11
Identifiers
Aliases	HDAC11, HD11, histone deacetylase 11
External IDs	OMIM: 607226; MGI: 2385252; HomoloGene: 11743; GeneCards: HDAC11; OMA:HDAC11 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	13,506,424 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	91,151,674 bp
RNA expression pattern
	Top expressed in
	left testis; ; inferior ganglion of vagus nerve; ; right testis; ; putamen; ; Amygdala; ; caudate nucleus; ; C1 segment; ; nucleus accumbens; ; prefrontal cortex; ; globus pallidus;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; superior colliculus; ; dorsal tegmental nucleus; ; ventral tegmental area; ; lateral hypothalamus; ; paraventricular nucleus of hypothalamus; ; anterior amygdaloid area; ; ventromedial nucleus; ; central gray substance of midbrain; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific); transcription factor binding; hydrolase activity; histone deacetylase activity; protein binding;
Cellular component	histone deacetylase complex; plasma membrane; nucleus;
Biological process	histone H3 deacetylation; oligodendrocyte development; regulation of transcription, DNA-templated; histone deacetylation; transcription, DNA-templated; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	79885
	232232
	ENSG00000163517
	ENSMUSG00000034245
	Q96DB2
	Q91WA3
	NM_001136041; NM_024827; NM_001330636
	NM_144919
	NP_001129513; NP_001317565; NP_079103
	NP_659168
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice.

It is the only Class IV HDAC since it is not highly homologous with either Rpd3 or hda1 yeast enzymes and so does not fit into either Class I or Class II. It is the smallest HDAC isoform and it was first described in 2002.