HDAC3

HDAC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4A69
Identifiers
Aliases	HDAC3, HD3, RPD3, RPD3-2, histone deacetylase 3
External IDs	OMIM: 605166; MGI: 1343091; HomoloGene: 48250; GeneCards: HDAC3; OMA:HDAC3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	141,636,870 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	38,088,069 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; skin of leg; ; granulocyte; ; skin of abdomen; ; anterior pituitary; ; right ovary; ; right lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; ventricular zone; ; genital tubercle; ; tail of embryo; ; superior frontal gyrus; ; muscle of thigh; ; lip; ; yolk sac; ; primary visual cortex; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific); transcription corepressor activity; histone deacetylase activity; protein deacetylase activity; transcription factor binding; histone deacetylase binding; chromatin binding; NF-kappaB binding; protein binding; enzyme binding; hydrolase activity; cyclin binding;
Cellular component	cytoplasm; histone deacetylase complex; cytosol; Golgi apparatus; plasma membrane; transcription repressor complex; nucleoplasm; spindle microtubule; nucleus; mitotic spindle;
Biological process	histone H3 deacetylation; positive regulation of protein phosphorylation; regulation of transcription, DNA-templated; regulation of protein stability; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; cellular response to fluid shear stress; transcription, DNA-templated; spindle assembly; protein deacetylation; negative regulation of JNK cascade; circadian rhythm; negative regulation of myotube differentiation; negative regulation of transcription, DNA-templated; histone deacetylation; positive regulation of TOR signaling; positive regulation of transcription by RNA polymerase II; negative regulation of nucleic acid-templated transcription; regulation of lipid metabolic process; chromatin organization; positive regulation of protein import into nucleus; histone H4 deacetylation; positive regulation of cold-induced thermogenesis; positive regulation of protein ubiquitination; circadian regulation of gene expression; regulation of circadian rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	8841
	15183
	ENSG00000171720
	ENSMUSG00000024454
	O15379
	O88895
	NM_003883
	NM_010411
	NP_003874; NP_001341968; NP_001341969; NP_001341970
	NP_034541
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.