Histone deacetylase 5

HDAC5
Identifiers
Aliases	HDAC5, HD5, NY-CO-9, histone deacetylase 5
External IDs	OMIM: 605315; MGI: 1333784; HomoloGene: 3995; GeneCards: HDAC5; OMA:HDAC5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	44,123,702 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	102,230,166 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; ganglionic eminence; ; muscle of thigh; ; right frontal lobe; ; popliteal artery; ; tibial arteries; ; right hemisphere of cerebellum; ; apex of heart; ; gastric mucosa;
	Top expressed in
	neural layer of retina; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; lip; ; muscle of thigh; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific); protein deacetylase activity; histone deacetylase binding; chromatin binding; metal ion binding; protein binding; hydrolase activity; protein kinase C binding; histone deacetylase activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	Golgi apparatus; histone deacetylase complex; cytoplasm; nucleus; nucleoplasm; cytosol; nuclear speck; protein-containing complex;
Biological process	histone H3 deacetylation; chromatin remodeling; regulation of myotube differentiation; regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; positive regulation of DNA-binding transcription factor activity; regulation of histone H3-K9 acetylation; response to activity; transcription, DNA-templated; protein deacetylation; negative regulation of cell migration involved in sprouting angiogenesis; B cell activation; neuron differentiation; negative regulation of myotube differentiation; cellular response to insulin stimulus; B cell differentiation; inflammatory response; regulation of protein binding; negative regulation of transcription, DNA-templated; cellular response to lipopolysaccharide; positive regulation of transcription by RNA polymerase II; response to cocaine; negative regulation of transcription by RNA polymerase II; histone deacetylation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	10014
	15184
	ENSG00000108840
	ENSMUSG00000008855
	Q9UQL6
	Q9Z2V6
	NM_001015053; NM_005474; NM_139205; NM_001382393
NM_001077696; NM_001284248; NM_001284249; NM_001284250; NM_010412;
	NM_001361596
	NP_001015053; NP_005465; NP_001369322
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.