HDAC8

HDAC8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T64, 1T67, 1T69, 1VKG, 1W22, 2V5W, 2V5X, 3EW8, 3EWF, 3EZP, 3EZT, 3F06, 3F07, 3F0R, 3MZ3, 3MZ4, 3MZ6, 3MZ7, 3RQD, 3SFF, 3SFH, 4QA0, 4QA1, 4QA2, 4QA3, 4QA4, 4QA5, 4QA6, 4QA7, 4RN0, 4RN1, 4RN2, 5DC7, 5D1D, 5D1C, 5DC8, 5D1B, 5DC5, 5DC6, 5BWZ
Identifiers
Aliases	HDAC8, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS, CDA07, histone deacetylase 8, KDAC8
External IDs	OMIM: 300269; MGI: 1917565; HomoloGene: 41274; GeneCards: HDAC8; OMA:HDAC8 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	72,573,101 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	101,548,965 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; left adrenal gland; ; left adrenal cortex; ; right adrenal gland; ; tendon of biceps brachii; ; right adrenal cortex; ; gonad; ; Achilles tendon; ; cerebellar hemisphere; ; anterior pituitary;
	Top expressed in
	wall of esophagus; ; mucosa of esophagus; ; epithelium of esophagus; ; ventricular zone; ; Rathke's pouch; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord; ; right kidney; ; zygote; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	Hsp90 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); histone deacetylase activity; metal ion binding; Hsp70 protein binding; protein binding; hydrolase activity; chromatin binding; transcription factor binding; deacetylase activity;
Cellular component	cytoplasm; histone deacetylase complex; cytosol; plasma membrane; nucleoplasm; nuclear chromosome; nucleus;
Biological process	histone H3 deacetylation; regulation of transcription, DNA-templated; regulation of protein stability; regulation of telomere maintenance; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; sister chromatid cohesion; regulation of cohesin loading; negative regulation of protein ubiquitination; histone deacetylation; negative regulation of gene expression; cellular response to trichostatin A; negative regulation of osteoblast differentiation; cellular response to forskolin; negative regulation of histone H3-K9 acetylation; chromatin organization; positive regulation of transcription by RNA polymerase II; histone H4 deacetylation;
	Sources:Amigo / QuickGO
Orthologs
	55869
	70315
	ENSG00000147099
	ENSMUSG00000067567
	Q9BY41
	Q8VH37
NM_001166418; NM_001166419; NM_001166420; NM_001166422; NM_001166448;
	NM_018486
	NM_027382; NM_001313742
NP_001159890; NP_001159891; NP_001159892; NP_001159894; NP_001159920;
	NP_060956
	NP_001300671; NP_081658
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene.