HECW2

HECW2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LFE
Identifiers
Aliases	HECW2, NEDL2, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2, NDHSAL
External IDs	OMIM: 617245; MGI: 2685817; HomoloGene: 66192; GeneCards: HECW2; OMA:HECW2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	196,593,684 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	54,234,327 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; Brodmann area 23; ; middle temporal gyrus; ; visceral pleura; ; testicle; ; upper lobe of lung; ; upper lobe of left lung; ; right lung; ; primary visual cortex; ; Brodmann area 46;
	Top expressed in
	epithelium of stomach; ; lumbar subsegment of spinal cord; ; substantia nigra; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; primary motor cortex; ; habenula; ; medial dorsal nucleus; ; prefrontal cortex; ; lobe of cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; ubiquitin-protein transferase activity; protein binding; ubiquitin protein ligase activity;
Cellular component	mitotic spindle; spindle; cytoskeleton; cytoplasm;
Biological process	protein ubiquitination; regulation of mitotic metaphase/anaphase transition; proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; regulation of dendrite morphogenesis; negative regulation of sodium ion transmembrane transporter activity;
	Sources:Amigo / QuickGO
Orthologs
	57520
	329152
	ENSG00000138411
	ENSMUSG00000042807
	Q9P2P5
	Q6I6G8
	NM_001304840; NM_020760; NM_001348768
	NM_001001883; NM_172655
	NP_001291769; NP_065811; NP_001335697
	NP_001001883; NP_766243
	Wikidata
View/Edit Human	View/Edit Mouse

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 is a protein that in humans is encoded by the HECW2 gene.