HERC5

HERC5
Identifiers
Aliases	HERC5, CEB1, CEBP1, HECT and RLD domain containing E3 ubiquitin protein ligase 5
External IDs	OMIM: 608242; HomoloGene: 81848; GeneCards: HERC5; OMA:HERC5 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	88,506,163 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; right testis; ; sperm; ; left testis; ; germinal epithelium; ; monocyte; ; palpebral conjunctiva; ; body of uterus; ; left ovary;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ISG15 transferase activity; protein binding; transferase activity; RNA binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity;
Cellular component	perinuclear region of cytoplasm; cytosol; cytoplasm;
Biological process	ISG15-protein conjugation; negative regulation of type I interferon production; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of defense response to virus; defense response to virus; immune system process; protein polyubiquitination; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	51191
	n/a
	ENSG00000138646
	n/a
	Q9UII4
	n/a
	NM_016323
	n/a
	NP_057407
	n/a
	Wikidata
View/Edit Human

E3 ISG15–protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. HERC5 has been shown to exhibit antiviral activity towards HIV-1, influenza A virus and human papillomavirus.