HERPUD1

HERPUD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGD
Identifiers
Aliases	HERPUD1, HERP, Mif1, SUP, homocysteine inducible ER protein with ubiquitin like domain 1
External IDs	OMIM: 608070; MGI: 1927406; HomoloGene: 40973; GeneCards: HERPUD1; OMA:HERPUD1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,944,864 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,122,005 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; tonsil; ; trachea; ; tibia; ; parietal pleura; ; rectum; ; olfactory bulb; ; pylorus;
	Top expressed in
	lacrimal gland; ; parotid gland; ; right kidney; ; seminal vesicula; ; submandibular gland; ; left lobe of liver; ; islet of Langerhans; ; pyloric antrum; ; calvaria; ; gallbladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter binding; protein binding; molecular function; ubiquitin ligase-substrate adaptor activity;
Cellular component	integral component of membrane; Lewy body core; calcium channel complex; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ubiquitin-dependent protein catabolic process; negative regulation of intrinsic apoptotic signaling pathway; regulation of protein ubiquitination; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; cellular calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; response to endoplasmic reticulum stress; PERK-mediated unfolded protein response; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; regulation of ER-associated ubiquitin-dependent protein catabolic process; response to unfolded protein; retrograde protein transport, ER to cytosol; positive regulation of protein binding; endoplasmic reticulum unfolded protein response; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	9709
	64209
	ENSG00000051108
	ENSMUSG00000031770
	Q15011
	Q9JJK5
	NM_001010989; NM_001010990; NM_001272103; NM_014685
	NM_022331; NM_001357205
	NP_001010989; NP_001259032; NP_055500; NP_001259032.1
	NP_071726; NP_001344134
	Wikidata
View/Edit Human	View/Edit Mouse

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein is a protein that in humans is encoded by the HERPUD1 gene.

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.