HES4

HES4
Identifiers
Aliases	HES4, bHLHb42, hes family bHLH transcription factor 4
External IDs	OMIM: 608060; GeneCards: HES4; OMA:HES4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,000,172 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; popliteal artery; ; tibial arteries; ; olfactory zone of nasal mucosa; ; apex of heart; ; coronary artery; ; left coronary artery; ; right coronary artery; ; putamen; ; ganglionic eminence;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; transcription factor binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; sequence-specific DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	nucleus;
Biological process	multicellular organism development; cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; nervous system development; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; somitogenesis; Notch signaling pathway; regulation of neurogenesis; negative regulation of nucleic acid-templated transcription; anterior/posterior pattern specification; negative regulation of neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	57801
	n/a
	ENSG00000188290
	n/a
	Q9HCC6
	n/a
	NM_001142467; NM_021170
	n/a
	NP_001135939; NP_066993
	n/a
	Wikidata
View/Edit Human

Hes Family BHLH Transcription Factor 4 (HES4) is a protein encoded by a gene of the same name located on chromosome 1 in humans. It does not currently have a known mouse ortholog.

HES4 plays a major role in key developmental processes, particularly in the immune system and bone formation. As a member of the basic helix-loop-helix (bHLH) family of transcription factors, HES4 plays a crucial role in T-cell development by responding to Notch1 signaling, which is vital for guiding hematopoietic progenitor cells toward becoming T-cells.

Additionally, HES4 has emerged as a significant factor in the context of osteosarcoma (OS), a type of bone cancer, where its expression correlates with aggressive tumor behavior and poor patient prognosis.