HESX1

HESX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K40
Identifiers
Aliases	HESX1, ANF, CPHD5, RPX, HESX homeobox 1
External IDs	OMIM: 601802; MGI: 96071; HomoloGene: 20831; GeneCards: HESX1; OMA:HESX1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	57,227,606 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	26,724,286 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; testicle; ; gonad; ; right testis; ; left testis; ; ventricular zone; ; C1 segment; ; right lobe of liver; ; right adrenal gland; ; right adrenal cortex;
	Top expressed in
	blastocyst; ; Rathke's pouch; ; embryo; ; embryo; ; endoderm; ; morula; ; epiblast; ; definitive endoderm; ; yolk sac; ; Stomodeum;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; protein C-terminus binding; chromatin binding; protein binding; protein N-terminus binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; forebrain morphogenesis; brain development; nose development; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; otic vesicle formation; negative regulation of transcription by RNA polymerase II; pituitary gland development; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8820
	15209
	ENSG00000163666
	ENSMUSG00000040726
	Q9UBX0
	Q61658
	NM_003865; NM_001376058; NM_001376059; NM_001376060; NM_001376061
	NM_010420
	NP_003856; NP_001362987; NP_001362988; NP_001362989; NP_001362990
	NP_034550
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox expressed in ES cells 1, also known as homeobox protein ANF, is a homeobox protein that in humans is encoded by the HESX1 gene.

Expression of HEX1 and HESX1 marks the anterior visceral endoderm of the embryo. The AVE is an extra-embryonic tissue, key to the establishment of the anterior-posterior body axis.