HEYL

HEYL
Identifiers
Aliases	HEYL, HESR3, HEY3, HRT3, bHLHb33, hes related family bHLH transcription factor with YRPW motif-like, hes related family bHLH transcription factor with YRPW motif like
External IDs	OMIM: 609034; MGI: 1860511; HomoloGene: 8494; GeneCards: HEYL; OMA:HEYL - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	39,639,643 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	123,143,668 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; left coronary artery; ; body of pancreas; ; tibial arteries; ; ascending aorta; ; apex of heart; ; right auricle of heart; ; Descending thoracic aorta; ; right lung; ; left ventricle;
	Top expressed in
	ascending aorta; ; vasculature of trunk; ; external carotid artery; ; aortic valve; ; internal carotid artery; ; pelvic ganglion; ; spinal nerve; ; urethra; ; female urethra; ; tunica media of zone of aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microsatellite binding; DNA binding; sequence-specific DNA binding; transcription corepressor activity; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; protein binding; protein heterodimerization activity; AF-1 domain binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II general transcription initiation factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific double-stranded DNA binding;
Cellular component	nucleoplasm; nucleus; cytoplasm;
Biological process	regulation of transcription, DNA-templated; negative regulation of androgen receptor signaling pathway; cellular response to BMP stimulus; glomerulus development; transcription by RNA polymerase II; negative regulation of gene expression; transcription, DNA-templated; multicellular organism development; proximal tubule development; skeletal muscle cell differentiation; Notch signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; outflow tract morphogenesis; atrioventricular valve morphogenesis; cardiac ventricle morphogenesis; cardiac epithelial to mesenchymal transition; mesenchymal cell development; pulmonary valve morphogenesis; epithelial to mesenchymal transition involved in endocardial cushion formation; ventricular septum morphogenesis; endocardial cushion morphogenesis; negative regulation of transcription, DNA-templated; positive regulation of transcription of Notch receptor target; blood vessel development; heart development; cell differentiation; regulation of neurogenesis; negative regulation of DNA-binding transcription factor activity; aortic valve morphogenesis; Notch signaling involved in heart development; anterior/posterior pattern specification; circulatory system development;
	Sources:Amigo / QuickGO
Orthologs
	26508
	56198
	ENSG00000163909
	ENSMUSG00000032744
	Q9NQ87
	Q9DBX7
	NM_014571
	NM_013905
	NP_055386
	NP_038933
	Wikidata
View/Edit Human	View/Edit Mouse

Hairy/enhancer-of-split related with YRPW motif-like protein is a protein that in humans is encoded by the HEYL gene.

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.