HGFAC

HGFAC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YBW, 1YC0, 2R0K, 2R0L, 2WUB, 2WUC, 3K2U
Identifiers
Aliases	HGFAC, HGFA, HGF activator
External IDs	OMIM: 604552; MGI: 1859281; HomoloGene: 1170; GeneCards: HGFAC; OMA:HGFAC - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	3,449,486 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	35,205,805 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right testis; ; left testis; ; right hemisphere of cerebellum; ; right uterine tube; ; ganglionic eminence; ; testicle; ; right frontal lobe; ; ventricular zone; ; anterior pituitary;
	Top expressed in
	left lobe of liver; ; crypt of lieberkuhn of small intestine; ; large intestine; ; islet of Langerhans; ; left colon; ; duodenum; ; pyloric antrum; ; fetal liver hematopoietic progenitor cell; ; right kidney; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	extracellular region; extracellular space; cytosol; rough endoplasmic reticulum;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	3083
	54426
	ENSG00000109758
	ENSMUSG00000029102
	Q04756
	Q9R098
	NM_001297439; NM_001528
	NM_019447
	NP_001284368; NP_001519
	NP_062320
	Wikidata
View/Edit Human	View/Edit Mouse

Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.

The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.