HHEX

HHEX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E1O
Identifiers
Aliases	HHEX, HEX, HMPH, HOX11L-PEN, PRH, PRHX, hematopoietically expressed homeobox
External IDs	OMIM: 604420; MGI: 96086; HomoloGene: 31110; GeneCards: HHEX; OMA:HHEX - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	92,695,647 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	37,429,179 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; monocyte; ; right lobe of liver; ; granulocyte; ; spleen; ; body of pancreas; ; gallbladder; ; blood;
	Top expressed in
	renal medulla; ; primary oocyte; ; outer renal medulla; ; granulocyte; ; adrenal gland; ; zygote; ; liver; ; spleen; ; inner renal medulla; ; secondary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein homodimerization activity; DNA-binding transcription factor activity; HMG box domain binding; transcription factor binding; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; eukaryotic initiation factor 4E binding; TBP-class protein binding; DNA binding, bending; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; protein-DNA complex; nucleus;
Biological process	Notch signaling pathway; myeloid leukocyte differentiation; endoderm development; DNA conformation change; regulation of transcription, DNA-templated; primary lung bud formation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; multicellular organism growth; embryonic organ development; regulation of transcription by RNA polymerase II; negative regulation of vascular endothelial growth factor receptor signaling pathway; interkinetic nuclear migration; negative regulation of transcription by competitive promoter binding; hepatocyte differentiation; in utero embryonic development; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; tissue morphogenesis; mRNA export from nucleus; transcription, DNA-templated; embryonic heart tube development; vasculogenesis; morphogenesis of an epithelium; poly(A)+ mRNA export from nucleus; positive regulation of Wnt signaling pathway; forebrain morphogenesis; multicellular organism development; hepatoblast differentiation; thyroid gland development; common bile duct development; regulation of cell population proliferation; protein localization to nucleus; gall bladder development; negative regulation of angiogenesis; pancreas development; animal organ morphogenesis; B cell differentiation; hepatic duct development; liver development; negative regulation of transcription by transcription factor localization; forebrain development; cell population proliferation; negative regulation of transcription, DNA-templated; primitive streak formation; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; signal transduction; response to peptide hormone; response to wounding; cell differentiation; hemopoiesis; regulation of leukocyte proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3087
	15242
	ENSG00000152804
	ENSMUSG00000024986
	Q03014
	P43120
	NM_002729
	NM_008245
	NP_002720
	NP_032271
	Wikidata
View/Edit Human	View/Edit Mouse

Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene and also known as Proline Rich Homeodomain protein PRH.

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation but the expression of this protein is not limited to hematopoietic cells.