HHIP

HHIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WFT, 2WFX, 2WG3, 2WG4, 3HO3, 3HO4, 3HO5
Identifiers
Aliases	HHIP, HIP, hedgehog interacting protein
External IDs	OMIM: 606178; MGI: 1341847; HomoloGene: 32469; GeneCards: HHIP; OMA:HHIP - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	144,745,271 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	80,784,635 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; endothelial cell; ; globus pallidus; ; inferior ganglion of vagus nerve; ; internal globus pallidus; ; external globus pallidus; ; tibia; ; subthalamic nucleus; ; synovial joint; ; epithelium of colon;
	Top expressed in
	left lung lobe; ; membranous bone; ; habenula; ; Dermatocranium; ; maxilla; ; mandible; ; lumbar subsegment of spinal cord; ; molar; ; iris; ; rib;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; metal ion binding; protein binding; catalytic activity; hedgehog family protein binding;
Cellular component	cytoplasm; membrane; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; ciliary membrane; nucleus;
Biological process	negative regulation of smoothened signaling pathway; regulation of fibroblast growth factor receptor signaling pathway; skeletal system morphogenesis; animal organ morphogenesis; neuroblast proliferation; smoothened signaling pathway; negative regulation of signal transduction; dorsal/ventral pattern formation; epithelial tube branching involved in lung morphogenesis; signal transduction; negative regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	64399
	15245
	ENSG00000164161
	ENSMUSG00000064325
	Q96QV1
	Q7TN16
	NM_022475
	NM_020259
	NP_071920
	NP_064655
	Wikidata
View/Edit Human	View/Edit Mouse

Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene.

This gene encodes a protein similar to the mouse hedgehog interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.