HIF1AN

HIF1AN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H2K, 1H2L, 1H2M, 1H2N, 1IZ3, 1MZE, 1MZF, 1YCI, 2CGN, 2CGO, 2ILM, 2W0X, 2WA3, 2WA4, 2XUM, 2Y0I, 2YC0, 2YDE, 3D8C, 3KCX, 3KCY, 3OD4, 3P3N, 3P3P, 4AI8, 4B7E, 4B7K, 4BIO, 4JAA, 4NR1, 4Z2W, 4Z1V
Identifiers
Aliases	HIF1AN, FIH1, hypoxia inducible factor 1 alpha subunit inhibitor, hypoxia inducible factor 1 subunit alpha inhibitor, HIFAN
External IDs	OMIM: 606615; MGI: 2442345; HomoloGene: 9906; GeneCards: HIF1AN; OMA:HIF1AN - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	100,559,998 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	44,564,713 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; glutes; ; tendon of biceps brachii; ; stromal cell of endometrium; ; triceps brachii muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; islet of Langerhans;
	Top expressed in
	muscle of thigh; ; knee joint; ; skeletal muscle tissue; ; triceps brachii muscle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; tibialis anterior muscle; ; temporal muscle; ; digastric muscle; ; gastrocnemius muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; peptidyl-asparagine 3-dioxygenase activity; protein homodimerization activity; ankyrin repeat binding; zinc ion binding; dioxygenase activity; metal ion binding; NF-kappaB binding; Notch binding; protein binding; carboxylic acid binding; oxidoreductase activity; peptidyl-histidine dioxygenase activity; oxygen gasoreceptor activity; 2-oxoglutarate-dependent dioxygenase activity; hypoxia-inducible factor-asparagine oxygenase activity;
Cellular component	cytoplasm; nucleoplasm; perinuclear region of cytoplasm; nucleus; cytosol;
Biological process	regulation of transcription, DNA-templated; peptidyl-histidine hydroxylation; transcription, DNA-templated; peptidyl-aspartic acid hydroxylation; peptidyl-asparagine hydroxylation; positive regulation of myoblast differentiation; positive regulation of vasculogenesis; regulation of transcription from RNA polymerase II promoter in response to hypoxia; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	55662
	319594
	ENSG00000166135
	ENSMUSG00000036450
	Q9NWT6
	Q8BLR9
	NM_017902
	NM_176958
	NP_060372
	NP_795932
	Wikidata
View/Edit Human	View/Edit Mouse

Hypoxia-inducible factor 1-alpha inhibitor (FIH) is a protein that in humans is encoded by the HIF1AN gene.