HIGD1A

HIGD1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LOM
Identifiers
Aliases	HIGD1A, HIG1, RCF1a, HIG1 hypoxia inducible domain family member 1A
External IDs	MGI: 1930666; HomoloGene: 121937; GeneCards: HIGD1A; OMA:HIGD1A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	42,804,490 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	121,858,362 bp
RNA expression pattern
	Top expressed in
	rectum; ; gastric mucosa; ; C1 segment; ; mucosa of transverse colon; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; smooth muscle tissue; ; right auricle of heart;
	Top expressed in
	facial motor nucleus; ; embryo; ; right kidney; ; embryo; ; Region I of hippocampus proper; ; medial vestibular nucleus; ; ventral tegmental area; ; habenula; ; lateral septal nucleus; ; dorsal tegmental nucleus;
	More reference expression data
	; ;
	More reference expression data
Orthologs
	25994
	56295
	ENSG00000181061
	ENSMUSG00000038412
	Q9Y241
	Q9JLR9
	NM_014056; NM_001099668; NM_001099669
	NM_019814
	NP_001093138; NP_001093139; NP_054775
NP_062788; NP_001344766; NP_001344767; NP_001344768; NP_001344769;
	NP_001344770
	Wikidata
View/Edit Human	View/Edit Mouse

HIG1 domain family member 1A (HIGD1A), also known as hypoglycemia/hypoxia inducible mitochondrial protein1-a (HIMP1-a) and hypoxia induced gene 1 (HIG1), is a protein that in humans is encoded by the HIGD1A gene on chromosome 3. This protein promotes mitochondrial homeostasis and survival of cells under stress and is involved in inflammatory and hypoxia-related diseases, including atherosclerosis, ischemic heart disease, and Alzheimer's disease, as well as cancer.