HIRA

HIRA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I32
Identifiers
Aliases	HIRA, DGCR1, TUP1, TUPLE1, histone cell cycle regulator
External IDs	OMIM: 600237; MGI: 99430; HomoloGene: 48172; GeneCards: HIRA; OMA:HIRA - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	19,447,450 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	18,789,059 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; granulocyte; ; ventricular zone; ; ganglionic eminence; ; stromal cell of endometrium; ; gastrocnemius muscle; ; right frontal lobe; ; prefrontal cortex; ; thymus;
	Top expressed in
	ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; tail of embryo; ; superior frontal gyrus; ; primary visual cortex; ; genital tubercle; ; yolk sac; ; lip; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; protein binding; transcription corepressor activity; nucleosome binding; DNA binding;
Cellular component	PML body; extracellular exosome; nucleus; nucleoplasm; HIR complex; chromosome, centromeric region; protein-containing complex;
Biological process	regulation of transcription by RNA polymerase II; muscle cell differentiation; anatomical structure morphogenesis; regulation of transcription, DNA-templated; gastrulation; osteoblast differentiation; transcription, DNA-templated; negative regulation of nucleic acid-templated transcription; chromatin organization; mitotic sister chromatid segregation;
	Sources:Amigo / QuickGO
Orthologs
	7290
	15260
	ENSG00000100084
	ENSMUSG00000022702
	P54198
	Q61666
	NM_003325
	NM_001005228; NM_010435
	NP_003316
	NP_034565
	Wikidata
View/Edit Human	View/Edit Mouse

Protein HIRA is a protein that in humans is encoded by the HIRA gene. This gene is mapped to 22q11.21, centromeric to COMT.