Hexokinase I

HK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CZA, 1DGK, 1HKB, 1HKC, 1QHA, 4F9O, 4FOE, 4FOI, 4FPA, 4FPB
Identifiers
Aliases	HK1, HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1, hexokinase 1, HK, hexokinase, RP79, NEDVIBA
External IDs	OMIM: 142600; MGI: 96103; HomoloGene: 100530; GeneCards: HK1; OMA:HK1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	69,401,884 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,215,687 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; mucosa of pharynx; ; Pons; ; cardiac muscle tissue of right atrium; ; body of tongue; ; spinal ganglia; ; parotid gland; ; sperm; ; myocardium of left ventricle; ; superior vestibular nucleus;
	Top expressed in
	neural layer of retina; ; seminiferous tubule; ; spermatid; ; subiculum; ; piriform cortex; ; retinal pigment epithelium; ; dorsal tegmental nucleus; ; central gray substance of midbrain; ; dorsomedial hypothalamic nucleus; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; mannokinase activity; phosphotransferase activity, alcohol group as acceptor; kinase activity; glucose binding; catalytic activity; protein binding; fructokinase activity; ATP binding; glucokinase activity; hexokinase activity; peptidoglycan binding; identical protein binding;
Cellular component	cytosol; membrane; cilium; mitochondrial outer membrane; sperm principal piece; mitochondrion; membrane raft;
Biological process	glycolytic process; phosphorylation; canonical glycolysis; cellular glucose homeostasis; maintenance of protein location in mitochondrion; establishment of protein localization to mitochondrion; hexose metabolic process; metabolism; glucose 6-phosphate metabolic process; carbohydrate metabolic process; carbohydrate phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3098
	15275
	ENSG00000156515
	ENSMUSG00000037012
	P19367
	P17710
NM_000188; NM_033496; NM_033497; NM_033498; NM_033500;
	NM_001322364; NM_001322365; NM_001322366; NM_001322367; NM_001358263
	NM_001146100; NM_010438
NP_000179; NP_001309293; NP_001309294; NP_001309295; NP_001309296;
	NP_277031; NP_277032; NP_277033; NP_277035; NP_001345192
	NP_001139572; NP_034568
	Wikidata
View/Edit Human	View/Edit Mouse

Hexokinase I, also known as hexokinase A and HK1, is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]