Hexokinase III

HK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HM8
Identifiers
Aliases	HK3, HKIII, HXK3, hexokinase 3
External IDs	OMIM: 142570; MGI: 2670962; HomoloGene: 55633; GeneCards: HK3; OMA:HK3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	176,899,346 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,169,198 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; spleen; ; bone marrow cells; ; blood; ; upper lobe of left lung; ; trabecular bone; ; right lung; ; right adrenal cortex; ; appendix;
	Top expressed in
	granulocyte; ; bone marrow; ; stroma of bone marrow; ; mesenteric lymph nodes; ; calvaria; ; blood; ; embryo; ; spleen; ; liver; ; cartilage tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; mannokinase activity; hexokinase activity; phosphotransferase activity, alcohol group as acceptor; glucose binding; kinase activity; catalytic activity; fructokinase activity; ATP binding; glucokinase activity;
Cellular component	cytosol; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen;
Biological process	glycolytic process; phosphorylation; canonical glycolysis; cellular glucose homeostasis; carbohydrate phosphorylation; hexose metabolic process; metabolism; glucose 6-phosphate metabolic process; neutrophil degranulation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3101
	212032
	ENSG00000160883
	ENSMUSG00000025877
	P52790
	Q3TRM8
	NM_002115
	NM_001033245; NM_001206390; NM_001206391; NM_001206392
	NP_002106
	NP_001028417; NP_001193319; NP_001193320; NP_001193321
	Wikidata
View/Edit Human	View/Edit Mouse

Hexokinase III, also known as hexokinase C, is an enzyme which in humans is encoded by the Hk3 gene on chromosome 5. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Similar to hexokinases I and II, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]