HKA test

The HKA Test, named after Richard R. Hudson, Martin Kreitman, and Montserrat Aguadé, is a statistical test used in genetics to evaluate the predictions of the Neutral Theory of molecular evolution. By comparing the polymorphism within each species and the divergence observed between two species at two or more loci, the test can determine whether the observed difference is likely due to neutral evolution or rather due to adaptive evolution. Developed in 1987, the HKA test is a precursor to the McDonald–Kreitman test, which was derived in 1991. The HKA test is best used to look for balancing selection, recent selective sweeps or other variation-reducing forces.

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