HLA-DOA

HLA-DOA
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4I0P
Identifiers
Aliases	HLA-DOA, HLA-DNA, HLA-DZA, HLADZ, major histocompatibility complex, class II, DO alpha
External IDs	OMIM: 142930; MGI: 95924; HomoloGene: 1601; GeneCards: HLA-DOA; OMA:HLA-DOA - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,009,591 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,314,208 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; granulocyte; ; spleen; ; gallbladder; ; monocyte; ; blood; ; tonsil; ; upper lobe of left lung; ; right lung;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; blood; ; thymus; ; morula; ; submandibular gland; ; subcutaneous adipose tissue; ; embryo; ; primary oocyte; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	MHC class II receptor activity; protein binding; MHC class II protein complex binding;
Cellular component	integral component of membrane; lysosomal membrane; endosome; plasma membrane; lysosome; MHC class II protein complex; endosome membrane; membrane;
Biological process	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; negative regulation of antigen processing and presentation of peptide antigen via MHC class II; regulation of T cell differentiation; immune system process; signal transduction; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	3111
	15001
ENSG00000204252; ENSG00000230141; ENSG00000232962; ENSG00000235744; ENSG00000231558;
	ENSG00000206292; ENSG00000232957
	ENSMUSG00000024334
	P06340
	n/a
	NM_002119; NM_015851
	NM_008206
	NP_002110
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.