HLA-DQ6

HLA-DQ6
Illustration of HLA-DQ with bound peptide
Polymer typeMHC Class II, DQ cell surface antigen
Cis-haplotype Haplotype
isoform subtype DQA1 DQB1
DQ α1.3β6.1 DQ6.1 *0103 *0601
DQ α1.2β6.2 DQ6.2 *0102 *0602
DQ α1.3β6.3 DQ6.3 *0103 *0603
DQ α1.2β6.4 DQ6.4 *0102 *0604
Rare haplotypes
Cis-haplotype Haplotype
isoform subtype DQA1 DQB1
DQ α1.2β6.3 DQ6.3v *0102 *0603
DQ α1.3β6.2 DQ6.2v *0103 *0602
DQ α1.2β6.9 DQ6.9 *0102 *0609

HLA-DQ6 (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the antibody recognition of β6 subset of DQ β-chains. The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1*06 allele group. This group currently contains many common alleles, DQB1*0602 is the most common. HLA-DQ6 and DQB1*06 are almost synonymous in meaning. DQ6 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. For DQ6, however, cis-isoform pairing only occurs with DQ1 α-chains. There are many haplotypes of DQ6.

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