HLA-DQA2

HLA-DQA2
Identifiers
Aliases	HLA-DQA2, DX-ALPHA, HLA-DXA, HLA-DQA2 (gene), major histocompatibility complex, class II, DQ alpha 2, DC-alpha, HLA-DCA, DQA1
External IDs	OMIM: 613503; MGI: 95895; HomoloGene: 134076; GeneCards: HLA-DQA2; OMA:HLA-DQA2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,747,198 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,506,797 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; appendix; ; testicle; ; lymph node; ; duodenum; ; spleen; ; right coronary artery; ; upper lobe of left lung; ; right lung; ; mucosa of transverse colon;
	Top expressed in
	spleen; ; mesenteric lymph nodes; ; Paneth cell; ; thymus; ; submandibular gland; ; right lung; ; right lung lobe; ; tunica adventitia of aorta; ; skin of external ear; ; superior surface of tongue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	MHC class II receptor activity;
Cellular component	integral component of membrane; endocytic vesicle membrane; clathrin-coated endocytic vesicle membrane; endosome; Golgi apparatus; trans-Golgi network membrane; endoplasmic reticulum membrane; membrane; Golgi membrane; plasma membrane; transport vesicle membrane; integral component of plasma membrane; MHC class II protein complex; lysosomal membrane; endoplasmic reticulum; ER to Golgi transport vesicle membrane; lysosome; integral component of lumenal side of endoplasmic reticulum membrane; endosome membrane;
Biological process	antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; interferon-gamma-mediated signaling pathway; immune system process; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; immune response; T cell receptor signaling pathway; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	3118
	14960
ENSG00000231823; ENSG00000206301; ENSG00000257473; ENSG00000231526; ENSG00000225103;
	ENSG00000237541; ENSG00000223793; ENSG00000233192
	ENSMUSG00000036594
	P01906
P14434; P14437; P01910; P14435; P14438;
	P04228; P14436; P04227
	NM_020056
	NM_010378
	NP_064440
	NP_034508
	Wikidata
View/Edit Human	View/Edit Mouse

HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also known as HLA-DXA or DAAP-381D23.2, it is part of the human leukocyte antigen system.

The protein encoded by this gene is expressed, but unlike HLA-DQA1, it is apparently unable to heterodimerize with HLA class II beta chain paralogues. The low level of HLA-DQA2 expression is apparently due to impaired transcription factor binding to the HLA-DQA2 gene promoter.