HLA-F

HLA-F
Identifiers
Aliases	HLA-F, CDA12, HLA-5.4, HLA-CDA12, major histocompatibility complex, class I, F
External IDs	OMIM: 143110; MGI: 3647514; HomoloGene: 133121; GeneCards: HLA-F; OMA:HLA-F - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	29,738,528 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; blood; ; lymph node; ; appendix; ; monocyte; ; right lung; ; duodenum; ; upper lobe of left lung; ; bone marrow cells;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	TAP2 binding; TAP1 binding; signaling receptor binding; peptide antigen binding; protein binding; beta-2-microglobulin binding; 14-3-3 protein binding;
Cellular component	integral component of membrane; phagocytic vesicle membrane; early endosome membrane; membrane; Golgi membrane; plasma membrane; cell surface; endoplasmic reticulum; MHC class I protein complex; ER to Golgi transport vesicle membrane; integral component of lumenal side of endoplasmic reticulum membrane; recycling endosome membrane; extracellular space; lysosome; lysosomal membrane; endosome; external side of plasma membrane; MHC class Ib protein complex;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; interferon-gamma-mediated signaling pathway; immune system process; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; type I interferon signaling pathway; regulation of immune response; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; immune response; antigen processing and presentation of exogenous peptide antigen via MHC class Ib; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; negative regulation of T cell cytokine production; negative regulation of natural killer cell cytokine production; positive regulation of natural killer cell cytokine production; negative regulation of natural killer cell degranulation; positive regulation of natural killer cell degranulation; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of neuron death;
	Sources:Amigo / QuickGO
Orthologs
	3134
	630294
ENSG00000229698; ENSG00000237508; ENSG00000234487; ENSG00000206509; ENSG00000137403;
	ENSG00000235220; ENSG00000204642
	n/a
	P30511
	Q0WXH6
	NM_001098478; NM_001098479; NM_018950
	NM_001177467
	NP_001091948; NP_001091949; NP_061823
	NP_001170938
	Wikidata
View/Edit Human	View/Edit Mouse

HLA class I histocompatibility antigen, alpha chain F is a protein that in humans is encoded by the HLA-F gene. It is an empty intracellular molecule that encodes a non-classical heavy chain anchored to the membrane and forming a heterodimer with a β-2 microglobulin light chain. It belongs to the HLA class I heavy chain paralogues that separate from most of the HLA heavy chains. HLA-F is localized in the endoplasmic reticulum and Golgi apparatus, and is also unique in the sense that it exhibits few polymorphisms in the human population relative to the other HLA genes; however, there have been found different isoforms from numerous transcript variants found for the HLA-F gene. Its pathways include IFN-gamma signaling and CDK-mediated phosphorylation (cyclin-dependent kinase) and removal of the Saccharomyces cerevisiae Cdc6 protein, which is crucial for functional DNA replication.