HMG20B

HMG20B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRJ
Identifiers
Aliases	HMG20B, BRAF25, BRAF35, HMGX2, HMGXB2, PP7706, SMARCE1r, SOXL, pp8857, high mobility group 20B
External IDs	OMIM: 605535; MGI: 1341190; HomoloGene: 74949; GeneCards: HMG20B; OMA:HMG20B - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,579,088 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,186,314 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; stromal cell of endometrium; ; olfactory zone of nasal mucosa; ; skin of leg; ; muscle layer of sigmoid colon; ; canal of the cervix; ; popliteal artery; ; tibial arteries; ; skin of abdomen; ; right uterine tube;
	Top expressed in
	interventricular septum; ; lip; ; yolk sac; ; genital tubercle; ; granulocyte; ; ventricular zone; ; lens; ; internal carotid artery; ; tail of embryo; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity; DNA binding; protein binding; histone deacetylase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; chromosome; nuclear body;
Biological process	skeletal muscle cell differentiation; cell cycle; negative regulation of protein sumoylation; blood coagulation; regulation of transcription, DNA-templated; positive regulation of neuron differentiation; transcription, DNA-templated; histone deacetylation; chromatin organization; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10362
	15353
	ENSG00000064961
	ENSMUSG00000020232
	Q9P0W2
	Q9Z104
	NM_006339
	NM_001163165; NM_001163166; NM_010440
	NP_006330
	NP_001156637; NP_001156638; NP_034570
	Wikidata
View/Edit Human	View/Edit Mouse

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.

HMG20B is a high-mobility group (HMG) DNA binding protein. HMG20B contains a carboxy terminal region that is essential for cytokinesis since it regulates cell cycle progression from the G2 phase into mitosis This carboxy terminal region of HMG20B interacts with the tumor suppressor protein BRCA2. A particular mutation in this region of the HMG20B gene is associated with lung cancer. This mutation interferes with the association of the HMG20B and BRCA2 proteins.