HMGA2

HMGA2
Identifiers
Aliases	HMGA2, BABL, HMGI-C, HMGIC, LIPO, STQTL9, high mobility group AT-hook 2, SRS5
External IDs	OMIM: 600698; MGI: 101761; HomoloGene: 136767; GeneCards: HMGA2; OMA:HMGA2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	65,966,291 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	120,312,374 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; embryo; ; stromal cell of endometrium; ; ventricular zone; ; cartilage tissue; ; ganglionic eminence; ; testicle; ; retinal pigment epithelium; ; buccal mucosa cell; ; amniotic fluid;
	Top expressed in
	genital tubercle; ; endothelial cell of lymphatic vessel; ; tail of embryo; ; abdominal wall; ; maxillary prominence; ; mandibular prominence; ; primitive streak; ; somite; ; hand; ; medullary collecting duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA-dependent protein kinase activity; MH1 domain binding; 5'-deoxyribose-5-phosphate lyase activity; minor groove of adenine-thymine-rich DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; C2H2 zinc finger domain binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; MH2 domain binding; protein binding; DNA-(apurinic or apyrimidinic site) endonuclease activity; nucleosomal DNA binding; DNA binding, bending; SMAD binding; cAMP response element binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coregulator activity;
Cellular component	SMAD protein complex; senescence-associated heterochromatin focus; nuclear chromosome; protein-DNA complex; chromatin; nucleus; nucleoplasm;
Biological process	positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; regulation of cell cycle process; regulation of transcription, DNA-templated; endodermal cell differentiation; chondrocyte differentiation; regulation of cellular response to drug; negative regulation of DNA binding; response to virus; regulation of stem cell population maintenance; negative regulation of apoptotic process; positive regulation of cellular response to X-ray; negative regulation of transcription by RNA polymerase II; chromatin organization; heterochromatin assembly; oncogene-induced cell senescence; stem cell differentiation; transcription, DNA-templated; multicellular organism development; positive regulation of transcription, DNA-templated; negative regulation by host of viral transcription; cell division; positive regulation of gene expression; mesenchymal cell differentiation; chromosome condensation; negative regulation of double-strand break repair via nonhomologous end joining; chondrocyte proliferation; positive regulation of cellular senescence; positive regulation of response to DNA damage stimulus; epithelial to mesenchymal transition; positive regulation of apoptotic process; mesodermal cell differentiation; regulation of growth; cell cycle; mitotic G2 DNA damage checkpoint signaling; negative regulation of transcription, DNA-templated; positive regulation of stem cell proliferation; fat cell differentiation; chromosome breakage; mesodermal-endodermal cell signaling; base-excision repair; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; transcription by RNA polymerase II; positive regulation of angiogenesis; positive regulation of cell proliferation in bone marrow; negative regulation of cellular senescence; positive regulation of protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8091
	15364
	ENSG00000149948
	ENSMUSG00000056758
	P52926
	P52927
NM_003484; NM_001015886; NM_001300918; NM_001300919; NM_003483;
	NM_001330190
	NM_010441; NM_001347170
	NP_001287847; NP_001287848; NP_001317119; NP_003474; NP_003475
	NP_001334099; NP_034571
	Wikidata
View/Edit Human	View/Edit Mouse

High-mobility group AT-hook 2, also known as HMGA2, is a protein that, in humans, is encoded by the HMGA2 gene.