HMGB1

HMGB1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2LY4, 2RTU, 2YRQ
Identifiers
Aliases	HMGB1, HMG1, HMG3, SBP-1, HMG-1, high mobility group box 1, HMGB-1
External IDs	OMIM: 163905; HomoloGene: 110676; GeneCards: HMGB1; OMA:HMGB1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	30,617,597 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; smooth muscle tissue; ; body of uterus; ; appendix; ; trabecular bone; ; rectum; ; C1 segment; ; canal of the cervix;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; bubble DNA binding; DNA polymerase binding; C-X-C chemokine binding; transcription factor binding; phosphatidylserine binding; lipopolysaccharide binding; lyase activity; single-stranded DNA binding; damaged DNA binding; protein binding; DNA binding, bending; supercoiled DNA binding; DNA binding; four-way junction DNA binding; RAGE receptor binding; chemoattractant activity; RNA binding; double-stranded DNA binding; double-stranded RNA binding; single-stranded RNA binding; cytokine activity; calcium-dependent protein kinase regulator activity; protein kinase activator activity; transcription coactivator activity; integrin binding;
Cellular component	cytoplasm; endosome; membrane; transcription repressor complex; extracellular region; nucleus; cell surface; plasma membrane; nucleoplasm; chromosome; condensed chromosome; endoplasmic reticulum-Golgi intermediate compartment; secretory granule lumen; ficolin-1-rich granule lumen; extracellular space; early endosome; neuron projection; alphav-beta3 integrin-HMGB1 complex;
Biological process	T-helper 1 cell activation; apoptotic DNA fragmentation; adaptive immune response; regulation of transcription by RNA polymerase II; positive regulation of DNA ligation; positive regulation of JNK cascade; cellular response to DNA damage stimulus; apoptotic cell clearance; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of toll-like receptor 9 signaling pathway; negative regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of dendritic cell differentiation; positive regulation of DNA binding; neuron projection development; negative regulation of blood vessel endothelial cell migration; positive regulation of interleukin-12 production; positive regulation of monocyte chemotaxis; activation of innate immune response; DNA ligation involved in DNA repair; innate immune response; inflammatory response; DNA repair; positive regulation of MAPK cascade; positive regulation of activated T cell proliferation; DNA geometric change; DNA recombination; inflammatory response to antigenic stimulus; positive regulation of interleukin-10 production; immune system process; negative regulation of transcription by RNA polymerase II; regulation of restriction endodeoxyribonuclease activity; chemotaxis; positive regulation of mismatch repair; negative regulation of CD4-positive, alpha-beta T cell differentiation; positive regulation of cytosolic calcium ion concentration; T-helper 1 cell differentiation; dendritic cell chemotaxis; autophagy; neutrophil clearance; V(D)J recombination; positive regulation of apoptotic process; DNA topological change; positive chemotaxis; toll-like receptor signaling pathway; neutrophil degranulation; eye development; myeloid dendritic cell activation; positive regulation of protein phosphorylation; endothelial cell proliferation; plasmacytoid dendritic cell activation; macrophage activation involved in immune response; regulation of tolerance induction; regulation of T cell mediated immune response to tumor cell; base-excision repair; regulation of autophagy; lung development; activation of protein kinase activity; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; endothelial cell chemotaxis; positive regulation of innate immune response; positive regulation of myeloid cell differentiation; positive regulation of glycogen catabolic process; regulation of protein kinase activity; positive regulation of transcription by RNA polymerase II; response to glucocorticoid; positive regulation of ERK1 and ERK2 cascade; positive regulation of wound healing; positive regulation of NIK/NF-kappaB signaling; positive regulation of sprouting angiogenesis; negative regulation of apoptotic cell clearance; regulation of nucleotide-excision repair; regulation of signaling receptor activity; chromatin remodeling; positive regulation of autophagy; developmental process; positive regulation of blood vessel endothelial cell migration; cell chemotaxis; cellular response to lipopolysaccharide; positive regulation of vascular endothelial cell proliferation; negative regulation of interferon-gamma production; positive regulation of monocyte chemotactic protein-1 production; cellular response to interleukin-7;
	Sources:Amigo / QuickGO
Orthologs
	3146
	n/a
	ENSG00000189403
	n/a
	P09429
	n/a
	NM_001313892; NM_001313893; NM_002128
	n/a
NP_001300821; NP_001300822; NP_002119; NP_001350590; NP_001357268;
	NP_001357269; NP_001357270; NP_001300821.1; NP_001300822.1; NP_002119.1
	n/a
	Wikidata
View/Edit Human

High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1 gene.

HMG-1 belongs to the high mobility group and contains a HMG-box domain.