HNF1A

HNF1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IC8, 2GYP
Identifiers
Aliases	HNF1A, HNF-1A, HNF1, IDDM20, LFB1, MODY3, TCF-1, TCF1, HNF1 homeobox A, HNF4A, HNF1alpha
External IDs	OMIM: 142410; MGI: 98504; HomoloGene: 459; GeneCards: HNF1A; OMA:HNF1A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	121,002,512 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	115,109,153 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; pancreatic ductal cell; ; human kidney; ; duodenum; ; body of pancreas; ; oocyte; ; jejunal mucosa; ; testicle; ; secondary oocyte;
	Top expressed in
	right kidney; ; yolk sac; ; female urethra; ; proximal tubule; ; embryo; ; supraoptic nucleus; ; stomach; ; embryo; ; blastocyst; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; protein heterodimerization activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; glucose homeostasis; regulation of transcription by RNA polymerase II; renal glucose absorption; insulin secretion; positive regulation of transcription initiation from RNA polymerase II promoter; transcription, DNA-templated; positive regulation of transcription, DNA-templated; glucose import; regulation of pronephros size; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; natural killer cell differentiation; liver development; pancreas development;
	Sources:Amigo / QuickGO
Orthologs
	6927
	21405
	ENSG00000135100
	ENSMUSG00000029556
	P20823
	P22361
	NM_000545; NM_001306179
	NM_009327
	NP_000536; NP_001293108; NP_000536.5; NP_001293108.1
	NP_033353
	Wikidata
View/Edit Human	View/Edit Mouse

HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. It is ubiquitously expressed in many tissues and cell types. The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes. Mutations in the HNF1A gene have been known to cause diabetes. The HNF1A gene also contains a SNP associated with increased risk of coronary artery disease.