Hepatocyte nuclear factor 4 alpha

HNF4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PZL, 3CBB, 3FS1, 4B7W, 4IQR
Identifiers
Aliases	HNF4A, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14, FRTS4, Hepatocyte nuclear factor 4 alpha, TCF-14
External IDs	OMIM: 600281; MGI: 109128; HomoloGene: 395; GeneCards: HNF4A; OMA:HNF4A - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	44,432,845 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	163,414,830 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; duodenum; ; rectum; ; mucosa of sigmoid colon; ; jejunal mucosa; ; human kidney; ; mucosa of ileum; ; islet of Langerhans; ; body of pancreas;
	Top expressed in
	Paneth cell; ; left colon; ; jejunum; ; crypt of lieberkuhn of small intestine; ; left lobe of liver; ; duodenum; ; yolk sac; ; pyloric antrum; ; human kidney; ; right kidney;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; zinc ion binding; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; signaling receptor binding; fatty acid binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cytoplasm; nucleoplasm;
Biological process	triglyceride homeostasis; ornithine metabolic process; phospholipid homeostasis; regulation of transcription, DNA-templated; SMAD protein signal transduction; glucose homeostasis; regulation of insulin secretion; lipid metabolism; regulation of transcription by RNA polymerase II; signal transduction involved in regulation of gene expression; sex differentiation; blood coagulation; response to glucose; transcription, DNA-templated; positive regulation of transcription, DNA-templated; regulation of lipid metabolic process; intracellular receptor signaling pathway; regulation of growth hormone receptor signaling pathway; negative regulation of cell growth; lipid homeostasis; xenobiotic metabolic process; transcription initiation from RNA polymerase II promoter; regulation of gastrulation; steroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; cholesterol homeostasis; type B pancreatic cell development; hepatocyte differentiation; regulation of circadian rhythm; negative regulation of transcription, DNA-templated; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	3172
	15378
	ENSG00000101076
	ENSMUSG00000017950
	P41235
	P49698
NM_000457; NM_001030003; NM_001030004; NM_001258355; NM_001287182;
	NM_001287183; NM_001287184; NM_175914; NM_178849; NM_178850
	NM_008261; NM_001312906; NM_001312907
NP_000448; NP_001025174; NP_001025175; NP_001245284; NP_001274111;
	NP_001274112; NP_001274113; NP_787110; NP_849180; NP_849181
	NP_001299835; NP_001299836; NP_032287
	Wikidata
View/Edit Human	View/Edit Mouse

Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is encoded by the HNF4A gene.