HNRNPA1

HNRNPA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HA1, 1L3K, 1PGZ, 1PO6, 1U1K, 1U1L, 1U1M, 1U1N, 1U1O, 1U1P, 1U1Q, 1U1R, 1UP1, 2H4M, 2LYV, 2UP1, 4YOE
Identifiers
Aliases	HNRNPA1, ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, hnRNP A1, hnRNP-A1, UP 1, heterogeneous nuclear ribonucleoprotein A1
External IDs	OMIM: 164017; MGI: 104820; HomoloGene: 134664; GeneCards: HNRNPA1; OMA:HNRNPA1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	103,155,119 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; parietal pleura; ; germinal epithelium; ; visceral pleura; ; tibia; ; caput epididymis; ; epithelium of colon; ; cartilage tissue; ; optic nerve;
	Top expressed in
	ventricular zone; ; tail of embryo; ; genital tubercle; ; neural layer of retina; ; embryo; ; yolk sac; ; embryo; ; medullary collecting duct; ; blastocyst; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	telomeric repeat-containing RNA binding; single-stranded DNA binding; protein binding; single-stranded RNA binding; G-rich strand telomeric DNA binding; nucleic acid binding; RNA binding; protein domain specific binding; pre-mRNA binding; miRNA binding; identical protein binding; mRNA binding;
Cellular component	cytoplasm; catalytic step 2 spliceosome; membrane; nucleoplasm; spliceosomal complex; extracellular exosome; nucleus; ribonucleoprotein complex;
Biological process	mRNA splicing, via spliceosome; mRNA transport; negative regulation of telomere maintenance via telomerase; RNA export from nucleus; mRNA processing; positive regulation of telomere maintenance via telomerase; nuclear export; viral process; import into nucleus; RNA splicing; fibroblast growth factor receptor signaling pathway; cellular response to sodium arsenite; regulation of alternative mRNA splicing, via spliceosome; RNA metabolic process; cellular response to glucose starvation; transport;
	Sources:Amigo / QuickGO
Orthologs
	3178
	15382
	ENSG00000135486
	ENSMUSG00000046434
	P09651
	P49312
	NM_002136; NM_031157
	NM_001039129; NM_010447
	NP_002127; NP_112420
	NP_001034218; NP_034577
	Wikidata
View/Edit Human	View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein A1 is a protein that in humans is encoded by the HNRNPA1 gene. Mutations in hnRNP A1 are causative of amyotrophic lateral sclerosis and the syndrome multisystem proteinopathy.